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Reliable data is the key to effective research, and is also fundamental to industrial analysis, so why should liquid handling be any different? Inaccurate liquid handling is currently responsible for the biggest laboratory error factor. If data isn't accurately collected it's more difficult to achieve reproducible experiments, and downstream analysis can be affected too. Smart pipette dispensers and other intelligent, highly equipped liquid handling tools from Hangzhou Zhongwang Technology Co., Ltd., are new generation of laboratory instrumentation designed to improve reliable and reproducible results
Elimination of Human Variability
Operator difference and environmental influences affect results It causes large variation between people, pipette and environment differences can have influences. Plunger speed, angle for pipetting, immersion depth and delay for pause cause different liquid delivery of pipettor among operator.
But with computer-controlled, motorized Smart Pipette Dispensers all those variations disappear. Your dispensing results will be the same no matter who is working at the machine because every dispense is performed with exactly the same protocol parameters. When you are working on sensitive experiments like real-time PCR, dose response, or compound screening you cannot afford the smallest variance in your sample dispense volumes.
When teams are performing multi-operator studies or multi-year trials, eliminating human error enables data collected by different operators to be compared over variety of conditions and over time, thus facilitating internal and external reproducibility of study outcomes.
Built-In Calibration and Quality Assurance
The cost and lost work-days due to outsourced calibration of traditional manual pipettes will eventually lead to time lag between calibration cycles when deviation may occur. The dispenser, smart and digital by nature, does however feature integrated quality control and in-house calibration. Many of the available smart dispensers are equipped with an in-line automatic volume verification that ensures both intended as delivered volume matches or falls within acceptable range of variability and tolerance levels.
RFID-tracked calibration ensures that the instrument is operating correctly at all time and provides in-time quality control before run, alerting staff of any impending error.
The quality-control system embedded in the dispensing pipeline ensures there is no hidden deviation in calibration as source for non reliable data.
Automation of Complex Protocols
When liquid handling protocols such as serial dilutions, preparation of plates and reaction mixtures are carried out by hand, there are numerous opportunities for error in many steps. Such cumulative errors are readily magnified and may result in data being seriously skewed. Smart pipette dispensers overcome these complexities by the use of pre-programmed sequences which can be repeated flawlessly on multiple occasions.
Smart dispensers are in fact highly versatile as they can run pre-programmed, multi step protocols consisting of, for example, dispense followed by mixing, then rinsing and transferring.
High amount laboratory will benefit enormously in this regard, as a protocol running can be trusted to be identical from the beginning to the end, regardless of the sample position or if the operator's attention wanders.
Real-Time Error Detection and Reporting
Despite being automated, the potential for error still exists, be it through the inclusion of air bubbles, pipette tip clogs, or not aspirating the correct volume. Smart pipette dispensers contain sensors that monitor the situation in real-time so that errors don’t make it to the final results, where they’ll be in trouble down the line.
The combination of capacitive level sensing and pressure monitoring can tell you about many potential problems, including blocked pipette tip, varying liquid levels, and unusual aspirations. If the situation arises, the instrument will stop the assay and flag the offending well, asking you to do something about it before there’s no telling what happened at this stage.
Not only that, some of the new generation systems create detailed logs that log everything that ever happened with this pipetting action, volumes, timings and error types. This guarantees full, traceable audit trial that’s both useful for quality control, and for meeting regulatory guidelines, cutting time-consuming hours investigating the “what and why” of confusing data.
Summary
With human variability removed, and data calibration, quality assurance and complex processes are integrated into few touches, it makes our smart pipette dispenser highly reliability to detect error in time. Thus, data in experiment can be highly convincing and scientist can pay attention to significant discovery. Hangzhou Zhongwang Technology Co., Ltd., endeavors in inventing efficient liquid dispensing instruments to facilitate the lab efficiency and accuracy. Welcome to inquire us.